How Much Can Pragmatic Free Trial Experts Earn?
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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of the study design, such as recruitment and consent in adherence, as well as the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causality of an intervention and its results. However, they should not be used to replace the need for explanation studies.
The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including the recruitment process, the design and implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to note that the majority of these trials were conducted in primary care settings.
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